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Home >> Antibodies >> VEGF-R1 / FLT-1

VEGF-R1 / FLT-1

Mouse Monoclonal Antibody [Clone FLT1/658]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified VEGF-R1 Mouse Monoclonal Antibody (FLT1/658). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Fms like tyrosine kinase 1 (Flt-1); Fms-like tyrosine kinase 1; FRT; Tyrosine protein kinase FRT; Tyrosine protein kinase receptor FLT; Vascular endothelial growth factor receptor 1 (VEGFR1); Vascular permeability factor receptor 1

Positive Control

293FT or A431 cells. Cerebellum or skin cancer.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Func.         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Functional Studies (Order Ab without BSA & Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human VEGF-R1 protein

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

150-180kDa

Specificity & Comments

Three cell membrane receptor tyrosine kinases, Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt-1 and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H. and Sato, M. 1990. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (Flt) closely related to the Fms family. Oncogene 5: 519-524.

Bioinformatics

  •  Entrez Gene ID: 2321
  •  Gene Symbol: FLT1
  •  SwissProt: P17948
  •  Chromosome Location: 13q12.13
  •  Unigene: 594454
NBT00658