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Home >> Antibodies >> Uroplakin 3A (Bladder Carcinoma Marker)

Uroplakin 3A (Bladder Carcinoma Marker)

Rabbit Polyclonal Antibody

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Western Blot Analysis in human HEK293 lysate in 1) absence and 2) presence of immunizing peptide using UPK3A Rabbit PAb.

Product Details

Synonyms

UP3a, UPIIIA, UPK3A, Uroplakin III (UPIII), Uroplakin3A

Positive Control

HEK293 cells. Bladder carcinoma.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

A synthetic peptide, aa260-279 (GASESSYTSVNRGPPLDRAE) of human UPK3A

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

-30kDa

Specificity & Comments

Uroplakin-3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. UPK3A also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. UPK3A has been shown as a helpful marker for the detection of bladder cancer.

Related Products



200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Key References

  1. Lai Y et. al. 2010. UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology 76, 514; 2009.

Bioinformatics

  •  Entrez Gene ID: 7380
  •  Gene Symbol: UPK3A
  •  SwissProt: O75631
  •  Chromosome Location: 22q13.31
  •  Unigene: 632787
NBT00409