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Uroplakin 3A (Bladder Carcinoma Marker) Antibody []

In Stock
Catalog Number Formulation Size Price
7380-RBP1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7380-RBP1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7380-RBP1-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml

Summary

Uroplakin-3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. UPK3A also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. UPK3A has been shown as a helpful marker for the detection of bladder cancer.

Product Properties & Targets

Antibody Type
Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Endoplasmic reticulum membrane
Gene Name
Positive Control
HEK293 cells. Bladder carcinoma.
Immunogen
A synthetic peptide, aa260-279 (GASESSYTSVNRGPPLDRAE) of human UPK3A
Alternate Names
Uroplakin-3a, Uroplakin III, UP3a, UPIIIA, UPK3A, Uroplakin III (UPIII), Uroplakin3A

Database Links

Entrez Gene ID
SwissProt

Additional Information

Chromosome Location
22q13.31
Mol. Weight of Antigen
30kDa

Functions

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

Key References

  • Lai Y et. al. 2010. UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology 76, 514; 2009.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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