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Uroplakin 3A (Bladder Carcinoma Marker) Antibody

Additional information

Catalog Number: 7380-RBP1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7380-RBP1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7380-RBP1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7380-RBP1-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Uroplakin 3A (Bladder Carcinoma Marker) Antibody

Western Blot Analysis in human HEK293 lysate in 1) absence and 2) presence of immunizing peptide using UPK3A Rabbit PAb.

  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Rabbit Polyclonals
Host
Rabbit
Applications
Western Blot
Species Reactivity
Human
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Endoplasmic reticulum membrane
Gene Name
UPK3A
Positive Control
HEK293 cells. Bladder carcinoma.
Immunogen
A synthetic peptide, aa260-279 (GASESSYTSVNRGPPLDRAE) of human UPK3A
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
Key References
  • Lai Y et. al. 2010. UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology 76, 514; 2009.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7380
SwissProt
O75631
Chromosome Location
22q13.31
Mol. Weight of Antigen
30kDa
Alternate Names
Uroplakin-3a, Uroplakin III, UP3a, UPIIIA, UPK3A, Uroplakin III (UPIII), Uroplakin3A

Summary

Uroplakin-3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. UPK3A also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. UPK3A has been shown as a helpful marker for the detection of bladder cancer.

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