Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).
Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).
SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.