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Home >> Antibodies >> SOX4 (Master Regulator of Epithelial-Mesenchymal Transition)

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition)

Mouse Monoclonal Antibody [Clone SOX4/2540]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).

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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).

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SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540).

Product Details

Synonyms

SOX; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; Transcription factor SOX-4

Positive Control

Breast or Colon Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human SOX4 protein

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

47kDa

Specificity & Comments

SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Neha Tiwari, et al. Cancer Cell, 23 (6), 2013; 768-783.

Bioinformatics

  •  Entrez Gene ID: 6659
  •  Gene Symbol: SOX4
  •  SwissProt: Q06945
  •  Chromosome Location: 6p22.3
  •  Unigene: 643910
NBT02540