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Home >> Antibodies >> SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker)

SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker)

Mouse Monoclonal Antibody [Clone SDHB/2382]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis of Purified SDHB Mouse Monoclonal Antibody (SDHB/2382). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using SDHB Mouse Monoclonal Antibody (SDHB/2382).

Product Details

Synonyms

CWS2; DHSB; Iron-sulfur subunit of complex II; PGL4; SDH2; SDHB; SDHIP; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein

Positive Control

Jurkat or HepG2 cells. Human kidney or liver.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 165-273) of human SDHB protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic (Mitochondria)

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

32kDa

Specificity & Comments

Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Allibhai, Z., et al. 2004. Malignant pheochromocytoma associated with germline mutation of the SDHB gene. J. Urol. 172: 1409-1410.

Bioinformatics

  •  Entrez Gene ID: 6390
  •  Gene Symbol: SDHB
  •  SwissProt: P21912
  •  Chromosome Location: 1p36.13
  •  Unigene: 465924
NBT02382