Formalin-fixed, paraffin-embedded human paraganglioma stained with SDHB Recombinant Rabbit Monoclonal Antibody (SDHB/6697R).
Formalin-fixed, paraffin-embedded human heart stained with SDHB Recombinant Rabbit Monoclonal Antibody (SDHB/6697R).
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.
