Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with p40 Rabbit Polyclonal Antibody.
Formalin-fixed, paraffin-embedded Lung Squamous Cell Carcinoma stained with p40 Rabbit Polyclonal Antibody.
Western Blot of HEK293 lysate (1) Absence and (2) Presence of immunizing peptide p40 Rabbit PAb.
SDS-PAGE Analysis Purified p40 Rabbit Polyclonal Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody's ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques.