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Home >> Antibodies >> NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis)

NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis)

Mouse Monoclonal Antibody [Clone CPTC-NME1-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified NME1 / nm23-H1 Mouse Monoclonal Antibody (CPTC-NME1-2). Confirmation of Purity and Integrity of Antibody.

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Western Blot Analysis of HeLa cell lysate using NME1 / nm23-H1 Mouse Monoclonal Antibody (CPTC-NME1-2).

Product Details

Synonyms

AWD; GAAD; Granzyme A activated DNase; Metastasis inhibition factor NM23; NB; NBS; NDP kinase A; NM23 long variant, included; NM23H1B; NME/NM23 nucleoside diphosphate kinase 1; NME1-NME2 spliced read-through transcript, included; Non-metastatic protein 23, homolog 1; Nucleoside diphosphate kinase A; Tumor metastatic process-associated protein

Positive Control

HepG2 or HeLa whole cell lysates. Human heart, brain, placenta and lung carcinoma.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NME1 protein

Cellular Localization

Cytoplasmic and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

23kDa

Specificity & Comments

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K). In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Steeg, P.S., et al. 1988. J. Natl. Cancer Inst. 80: 200-209

Bioinformatics

  •  Entrez Gene ID: 4830
  •  Gene Symbol: NME1
  •  SwissProt: P15531
  •  Chromosome Location: 17q21.33
  •  Unigene: 463456
NBT02247