Home >> Antibodies >> Lambda Light Chain (B-Cell Marker)

Lambda Light Chain (B-Cell Marker)

Recombinant Rabbit Monoclonal Antibody [Clone LLC/3774R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human spleen stained with Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human spleen stained with Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R).

SDS-PAGE Analysis Purified Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human spleen stained with Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human spleen stained with Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R).

SDS-PAGE Analysis Purified Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein

Positive Control

Human tonsil or spleen tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human IGL protein

Cellular Localization

Cell Surface, cytoplasmic and secreted

Species Reactivity

Human.

Host / Ig Isotype

Rabbit IgG

Mol. Weight of Antigen

~22.5kDa

Specificity & Comments

This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.