2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Interleukin-1 alpha (IL-1 alpha)

Interleukin-1 alpha (IL-1 alpha)

Mouse Monoclonal Antibody [Clone IL1A/3982]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human pancreas stained with Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982).

img

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982).

img

Analysis of Protein Array containing >19,000 full-length human proteins using Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982).

Product Details

Synonyms

BAF; FAF; Hematopoietin 1; IL 1 alpha; IL1F1; Interleukin 1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha

Positive Control

HeLa cells. Human colon carcinoma tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 113-271) of human IL1A protein

Cellular Localization

Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretor

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

33kDa (proprotein); 17kDa (mature)

Specificity & Comments

Two forms of interleukin-1, designated IL-1and IL-1, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1 and IL-1 bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Auron, P.E., et al. 1985. Nucleotide sequence of human monocyte inter-leukin-1 precursor cDNA. Proc. Natl. Acad. Sci. USA 81: 7907-7911.

Bioinformatics

  •  Entrez Gene ID: 3552
  •  Gene Symbol: IL1A
  •  SwissProt: P01583
  •  Chromosome Location: 2q13
  •  Unigene: 1722