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Home >> Antibodies >> Insulin-like Growth Factor-1 (IGF-1)

Insulin-like Growth Factor-1 (IGF-1)

Mouse Monoclonal Antibody [Clone SPM406]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

Insulin-like Growth Factor IA (IGF-IA); Insulin-like Growth Factor IB (IGF-IB); Mechano Growth Factor (MGF); Somatomedin-C

Positive Control

Pancreas or brain. Breast, Thyroid or Colon Cancers; IGF-1 recombinant protein.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF, IHC-P         More Details

ELISA (For coating, purchase antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)
In-vitro Neutralization of Biological Activity of IGF-1 (Order Ab without Azide)Optimal dilution for a specific application should be determined.

Immunogen

Purified human IGF-1 protein

Cellular Localization

Cytoplasmic (Secreted)

Species Reactivity

Human. Mouse. Rat. Rabbit.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~7.6kDa

Specificity & Comments

This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sandberg-Nordqvist AC, et. al. (1993) Cancer Res. 53: 2475-2478.
  2. Rotwein p, et. al. (1986) J. Biol. Chem. 261: 4828-4832.
  3. Zheng WH, et. al. (2000) J. Neural.Transm. Suppl. 2000: 261-272.

Bioinformatics

  •  Entrez Gene ID: 3479
  •  Gene Symbol: IGF1
  •  SwissProt: P05019
  •  Chromosome Location: 12q23.2
  •  Unigene: 160562
NBT00220