2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> HLA-DRB (MHC II)

HLA-DRB (MHC II)

Mouse Monoclonal Antibody [Clone Bra30]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00

Product Details

Synonyms

HLA class II histocompatibility antigen DR beta 3 chain; HLADR3B; Major histocompatibility complex, class II DR beta 3

Positive Control

Ramos, Daudi or HuT78 cells. Tonsil or lymph node.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human REH cells (non-T, non-B leukemia cell line)

Cellular Localization

Cell Surface

Species Reactivity

Human. Baboon. Chimpanzee. Monkey. Squirrel. Dog.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

~28kDa (beta chain)

Specificity & Comments

This MAb reacts with the HLA-DRB3 antigen, a member of MHC class II molecules.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Cresswell, P., 1996. Cell 84. 505-507
  2. Barclay, A.N., et al., eds. 1997. The Leucocyte Antigen Facts Book. Academic Press. London
  3. Seddon, B., and Mason, D., 1996. Int. Immunol. 8. 1185-1193

Bioinformatics

  •  Entrez Gene ID: 3123
  •  Gene Symbol: HLA-DRB3
  •  SwissProt: P01911
  •  Chromosome Location: 6p21.3
  •  Unigene: 534322
NBT00407