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Home >> Antibodies >> Granzyme B (NK/T-Cell Lymphoma Marker)

Granzyme B (NK/T-Cell Lymphoma Marker)

Mouse Monoclonal Antibody [Clone GZMB/2403]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified Granzyme B Mouse Monoclonal Antibody (GZMB/2403). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using Granzyme B Mouse Monoclonal Antibody (GZMB/2403)

Product Details

Synonyms

Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E

Positive Control

A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA) Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, lambda

Mol. Weight of Antigen

29-32kDa

Specificity & Comments

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Shresta, S., et al. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc. Natl. Acad. Sci. USA 92: 5679-5683.

Bioinformatics

  •  Entrez Gene ID: 3002
  •  Gene Symbol: GZMB
  •  SwissProt: P10144
  •  Chromosome Location: 14q11.2
  •  Unigene: 1051
NBT02403