Formalin-fixed, paraffin-embedded human Colon stained with Fodrin Mouse Monoclonal Antibody (SPTAN1/3351).
Formalin-fixed, paraffin-embedded human Tonsil stained with Fodrin Mouse Monoclonal Antibody (SPTAN1/3351).
SDS-PAGE Analysis Purified Fodrin Mouse Monoclonal Antibody (SPTAN1/3351). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Fodrin Mouse Monoclonal Antibody (SPTAN1/3351).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.