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Home >> Antibodies >> Endoglin / CD105 (Angiogenesis Marker)

Endoglin / CD105 (Angiogenesis Marker)

Mouse Monoclonal Antibody [Clone ENG/3269]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with Endoglin / CD105 Mouse Monoclonal Antibody (ENG/3269).

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Formalin-fixed, paraffin-embedded human Tonsil stained with Endoglin / CD105 Mouse Monoclonal Antibody (ENG/3269).

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SDS-PAGE Analysis Purified Endoglin / CD105 Mouse Monoclonal Antibody (ENG/3269). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Endoglin / CD105 Mouse Monoclonal Antibody (ENG/3269).

Product Details

Synonyms

CD105; END; Endoglin; Eng; HHT1; S-endoglin

Positive Control

HeLa, A431 or HL-60 cell lysates (WB). Human tonsil or placenta (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Endoglin protein fragment (aa74-251) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

84kDa

Specificity & Comments

CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Altomonte, M., et al. 1996. Expression and structural features of Endoglin (CD105), a transforming growth factor 1 and 3 binding protein, in human melanoma. Br. J. Cancer 74: 1586-1591.

Bioinformatics

  •  Entrez Gene ID: 2022
  •  Gene Symbol: ENG
  •  SwissProt: P17813
  •  Chromosome Location: 9q34.11
  •  Unigene: 76753
NBT03269