Formalin-fixed, paraffin-embedded human kidney stained with DAXX Mouse Monoclonal Antibody (PCRP-DAXX-8C2).
Immunofluorescence Analysis of PFA-fixed HeLa cells using DAXX Mouse Monoclonal Antibody (PCRP-DAXX-8C2) followed by goat anti-mouse IgG-CF488 (green).
SDS-PAGE Analysis Purified DAXX Mouse Monoclonal Antibody (PCRP-DAXX-8C2). Confirmation of Purity and Integrity of Antibody.
Flow cytometric analysis of PFA-fixed HeLa cells. DAXX Mouse Monoclonal Antibody (PCRP-DAXX-8C2) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.