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Home >> Antibodies >> Chromogranin A / CHGA (Neuroendocrine Marker)

Chromogranin A / CHGA (Neuroendocrine Marker)

Mouse Monoclonal Antibody [Clone CGA/413 + CHGA/777 + CHGA/798]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded Pheochromocytoma stained with Chromogranin A Monoclonal Antibody (CGA/413+ CHGA/777+ CHGA/798)

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Formalin-fixed, paraffin-embedded Pancreas stained with Chromogranin A Monoclonal Antibody (CGA/413+ CHGA/777+ CHGA/798)

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Formalin-fixed, paraffin-embedded Parathyroid stained with Chromogranin A Monoclonal Antibody (CGA/413+ CHGA/777+ CHGA/798)

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Formalin-fixed, paraffin-embedded Adrenal Gland stained with Chromogranin A Monoclonal Antibody (CGA/413+ CHGA/777+ CHGA/798)

Product Details

Synonyms

Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II

Positive Control

PC12 cells. Adrenal gland, bowel, thyroid, pancreas or pheochromocytoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human chromogranin A protein

Cellular Localization

Finely granular cytoplasmic

Species Reactivity

Human. Monkey. Pig. Mouse. Rat.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

68-75kDa

Specificity & Comments

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Konecki DS et. al. J Biol Chem 1987;262:17026-30.
  2. Lloyd RV et. al. Am J Pathol 1988; 130:296-304.

Bioinformatics

  •  Entrez Gene ID: 1113
  •  Gene Symbol: CHGA
  •  SwissProt: P10645
  •  Chromosome Location: 14q32.12
  •  Unigene: 150793
NBT01060