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Home >> Antibodies >> CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein)

CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein)

Mouse Monoclonal Antibody [Clone BCMA/2366]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with CD269 / TNFRSF17 Mouse Monoclonal Antibody (BCMA/2366).

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Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with CD269 / TNFRSF17 Mouse Monoclonal Antibody (BCMA/2366).

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SDS-PAGE Analysis Purified CD269 / TNFRSF17 Mouse Monoclonal Antibody (BCMA/2366). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using CD269 Mouse Monoclonal Antibody (BCMA/2366)

Product Details

Synonyms

B-cell maturation protein; BCMA; CD269; TNR17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

Positive Control

NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

20kDa

Specificity & Comments

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Laabi, Y., et al. 1992. EMBO J. 11: 3897-3904.

Bioinformatics

  •  Entrez Gene ID: 608
  •  Gene Symbol: CD269
  •  SwissProt: Q02223
  •  Chromosome Location: 16p13.13
  •  Unigene: 2556
NBT02366