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Home >> Antibodies >> CD26 (DPP IV / ADA-Binding Protein)

CD26 (DPP IV / ADA-Binding Protein)

Mouse Monoclonal Antibody [Clone 134-2C2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

ADA-binding protein (ADABP); Adenosine deaminase complexing protein 2 (ADCP-2); Dipeptidyl peptidase 4; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase, intestinal; Dipeptidylpeptidase 4; Dipeptidylpeptidase IV; DPP4; DPPIV; Intestinal dipeptidyl peptidase; T-cell activation antigen CD26; TP103

Positive Control

U-87 MG (Human glioblastoma astrocytoma), Ramos (Human Burkitt's lymphoma, HEP-G2 cells and lymphocytes. Lymph nodes and tonsils.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Frozen Only) (1-2ug/ml for 30 minutes at RT) Optimal dilution for a specific application should be determined.

Immunogen

A synthetic peptide from the amino terminal region of CD26

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgM, kappa

Mol. Weight of Antigen

110kDa

Specificity & Comments

Recognizes a glycoprotein of 110kDa, identified as CD26. It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Abbott CA. et. al. Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene. Immunogenetics 1994, 40:331-338.
  2. Valenzuela A et. al. HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. Adv Exp Med Biol 1997, 421:185-192.
  3. Fleischer B. CD26: a surface protease involved in T-cell activation. Immunol Today 1994, 15(4):180-184.
  4. Cheng HC, et al. Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin. J Biol Chem. 1998 273(37):24207-24015.

Bioinformatics

  •  Entrez Gene ID: 1803
  •  Gene Symbol: DPP4
  •  SwissProt: P27487
  •  Chromosome Location: 2q24.3
  •  Unigene: 368912
NBT00162