SDS-PAGE Analysis Purified ACE / CD143 Mouse Monoclonal Antibody (ACE/3762). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human colon stained with ACE / CD143 Mouse Monoclonal Antibody (ACE/3762).
Western Blot Analysis of human Kidney tissue lysate using ACE / CD143 Mouse Monoclonal Antibody (ACE/3762).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.