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Home >> Antibodies >> 14-3-3 Sigma / Stratifin
14-3-3 Sigma / Stratifin

Mouse Monoclonal Antibody [Clone CPTC-SFN-2]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Skin stained with Stratifin Mouse Monoclonal Antibody (CPTC-SFN-2).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using 14-3-3 Sigma / Stratifin Mouse Monoclonal Antibody (CPTC-SFN-2).

Product Details

Synonyms

SFN; HME1; Stratifin; YWHAS; 14-3-3 Sigma

Positive Control

Skin and tissues enriched in stratified squamous keratinizing epithelium. HaCaT, hTCEpi, A-431 cell lines.

Known Applications & Suggested Dilutions

WB, IHC-P         More Details
Western Blotting (0.5-1.0ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 min at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length SFNprotein

Cellular Localization

Cytoplasm and nucleus. May be secreted by a non-classical secretory pathway.

Species Reactivity

Human. Others-not tested.

Host / Ig Isotype

Mouse / IgG1, kappa

Specificity & Comments

SFN (stratifin) is a p53-induced tumor suppressor gene which is activated in response to DNA damage, causing cell cycle arrest at G2 phase by blocking cdc2-cyclin B1 complex from entering the nucleus. It is inactivated in breast, lung, prostate, liver and gastric cancer. It is associated with poor prognosis when its down-regulation is observed in epithelial ovarian cancer. SFN expression could contribute to cancer cell proliferation and the development and/or progression of human gastrointestinal cancer.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Pulukuri, S M, and J S Rao. Oncogene., U.S. National Library of Medicine, 3 Aug. 200

Bioinformatics

  •  Entrez Gene ID: 2810
  •  Gene Symbol: SFN
  •  SwissProt: P31947
  •  Chromosome Location: 1p36.11
  •  Unigene: 523718
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