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Recombinant CD71 / Transferrin Receptor (TFRC) Antibody [TFRC/13046R]

In Stock
Catalog Number Formulation Size Price
7037-RBM17-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7037-RBM17-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7037-RBM17-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD71 Antibody in SDS-PAGE

CD71 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified CD71 Recombinant Rabbit Monoclonal Antibody (TFRC/13046R). Confirmation of Purity and Integrity of Antibody.

Summary

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
ELISA
Species Reactivity
Human
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell membrane, Melanosome, Secreted
Gene Name
TFRC
Positive Control
Human placenta, bone marrow or lung.
Immunogen
Recombinant full-length human CD71 protein
Alternate Names
Transferrin receptor protein 1, CD71|IMD46|T9|TFR|TFR1|TR|TRFR|p90

Database Links

Entrez Gene ID
7037
SwissProt
P02786

Additional Information

Clone
TFRC/13046R
Chromosome Location
3q29
Mol. Weight of Antigen
84.87kDa
Expression System
CHO Cells
Purification
Protein A

Related Antibodies

View All TFRC Antibodies

Functions

  • Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity)., (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus., (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells., (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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