PARTNERSHIP OPPORTUNITIES
HLA class II histocompatibility antigen, DR alpha chain Rabbit Recombinant Monoclonal Antibody (MSVA-470R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides(CLIP) from an antigen binding groove in MHC II-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen bind-ing. Accumulating in endosomal / lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR,-DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules playa central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane-anchored heavy chain and a light chain (b-2-Microglobulin).Polymorphisms yield hundreds of HLA-B and -C alleles.
