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Recombinant CD106 / VCAM1 (Activated Endothelial Cell Marker) Antibody [1.4C3]

In Stock
Catalog Number Formulation Size Price
7412-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7412-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7412-MSM1-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD106 / VCAM1 (Activated Endothelial Cell Marker) Antibody

SDS-PAGE Analysis of Purified CD106 Monoclonal Antibody (1.4C3). Confirmation of Purity and Integrity of Antibody.

Recombinant CD106 / VCAM1 (Activated Endothelial Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Tonsil stained with CD106 Monoclonal Antibody (1.4C3).

Summary

Recognizes a protein of 110kDa, identified as CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1) and INCAM-100). CD106 is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. CD106 serves as a ligand for leukocyte integrin (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow, IF, IHC
Species Reactivity
Human
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
VCAM1
Positive Control
Human placenta or tonsil.
Immunogen
Stimulated human umbilical vein endothelial cells (HUVEC)
Alternate Names
Vascular cell adhesion protein 1, CD106|INCAM-100

Database Links

Entrez Gene ID
7412
SwissProt
P19320

Additional Information

Clone
1.4C3
Chromosome Location
1p21.2
Mol. Weight of Antigen
81.28kDa
Expression System
Hybridoma Cells
Purification
Protein G

Related Antibodies

View All VCAM1 Antibodies

Functions

  • Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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