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Gastrin Antibody [GAST/2635]

In Stock
Catalog Number Formulation Size Price
2520-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2520-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2520-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

Gastrin, is a hormone that normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets. Its primary function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. It also responsible for stimulating smooth muscle contraction and increasing blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome. Gastrin-Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones and also acts as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human Pituitary or Stomach.
Immunogen
Recombinant full-length human GAST protein
Alternate Names
Gastrin, Component II; GAS; Gast; Gastrin component I; Gastrin component II; Gastrin component III; Gastrin precursor; Gastrin-14; Gastrin-17; Gastrin-34; Gastrin-52; Gastrin-6; Gastrin-71

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
GAST/2635
Chromosome Location
17q21.2.
Mol. Weight of Antigen
2/4/14kDa

Functions

  • Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Key References

  • Gregory, R.A., et al. 1969. Gut 10: 603-608.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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