The platelet-derived growth factor receptor alpha (PDGFRA) has a molecular weight of approximately 170 kDa. This transmembrane receptor is expressed in various cell types, including fibroblasts, smooth muscle cells, and certain types of stem cells. It is particularly important during embryonic development and is also present in some adult tissues. PDGFRA is a receptor for platelet-derived growth factors (PDGFs), with its activation leading to signaling cascades that regulate cell proliferation, differentiation, and survival. Mutations, amplifications, or overexpression of PDGFRA are associated with certain cancers, particularly gastrointestinal stromal tumors (GISTs).
In cancer research, these antibodies against PDGFRA help identify the expression levels and localization of this receptor in tumor tissues, aiding in classifying tumors and selecting appropriate treatments. In diagnostics, PDGFRA immunohistochemistry is often used to confirm the diagnosis of GISTs, where activating mutations in PDGFRA are common.
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