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PDGFRA Antibodies

The platelet-derived growth factor receptor alpha (PDGFRA) has a molecular weight of approximately 170 kDa. This transmembrane receptor is expressed in various cell types, including fibroblasts, smooth muscle cells, and certain types of stem cells. It is particularly important during embryonic development and is also present in some adult tissues. It is a receptor for platelet-derived growth factors (PDGFs), with its activation leading to signaling cascades that regulate cell proliferation, differentiation, and survival. Mutations, amplifications, or overexpressions are associated with certain cancers, particularly gastrointestinal stromal tumors (GISTs).

In cancer research, these antibodies against PDGFRA help identify the expression levels and localization of this receptor in tumor tissues, aiding in classifying tumors and selecting appropriate treatments. In diagnostics, immunohistochemistry is often used to confirm the diagnosis of GISTs, where activating mutations in platelet-derived growth factor receptor alpha are common.

Synonyms

Platelet-derived growth factor receptor alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; PDGFR 2; PDGFRA/BCR fusion; Platelet derived growth factor receptor 2; Platelet derived growth factor receptor alpha polypeptide; Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA

Research Areas

Cardiovascular, AKT Signaling, Angiogenesis, Infectious Disease, Neural Stem Cells, Nuclear Marker, Signal Transduction

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PDGFRA

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