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Home >> Antibodies >> TOX3 / TNRC9

TOX3 / TNRC9

Mouse Monoclonal Antibody [Clone TOX3/1124]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Western Blot Analysis (A) Recombinant protein (B) A549 (C) A431 TOX3 Mouse Monoclonal Antibody (TOX3/1124).

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SDS-PAGE Analysis Purified TOX3 Mouse Monoclonal Antibody (TOX3/1124).

Product Details

Synonyms

TOX3; CAG trinucleotide repeat-containing gene F9 protein; CAGF9; TOX high mobility group box family member 3; Trinucleotide repeat containing 9 (TNRC9)

Positive Control

SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order Ab without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Cellular Localization

Cytoplasmic & Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

63kDa

Specificity & Comments

It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. O'Flaherty, E., et al. 2003. TOX defines a conserved subfamily of HMG-box proteins. BMC Genomics 4: 13.
  2. Smid, M., et al. 2006. Genes associated with breast cancer metastatic to bone. J. Clin. Oncol. 24: 2261-2267.

Bioinformatics

  •  Entrez Gene ID: 27324
  •  Gene Symbol: TOX3
  •  SwissProt: O15405
  •  Chromosome Location: 16q12.1
  •  Unigene: 460789
NBT01124