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Home >> Antibodies >> TGF-alpha (Transforming Growth Factor alpha)

TGF-alpha (Transforming Growth Factor alpha)

Mouse Monoclonal Antibody [Clone SPM357]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with TGF alpha Mouse Monoclonal Antibody (SPM357)

Product Details

Synonyms

EGF-like TGF; ETGF; TFGA; TGF Type 1; TGFA; Wa1; Waved 1

Positive Control

Jurkat or Ramos cells. Testicular Carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

A 17-amino acid synthetic peptide from the carboxyl-terminus of rat TGFα.

Cellular Localization

Cytoplasmic and Extracellular (secreted)

Species Reactivity

Human. Cow. Rat. Mouse.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~6kDa

Specificity & Comments

This antibody reacts with the C-terminus of TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with Ab-1 is completely blocked by the peptide used for raising this antibody. TGF (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kobrin MS et. al. J Bio Chem, 1986, 261:14414-9.
  2. Kudlow JE et. al. Endocrinology, 1987, 121(4):1577-9.
  3. Kobrin MS et. al. Endocrinology, 1987, 121(4):1412-6.
  4. Kudlow JE et. al. J Bio Chem, 1989, 264(7):3880-3

Bioinformatics

  •  Entrez Gene ID: 7039
  •  Gene Symbol: TGFA
  •  SwissProt: P01135
  •  Chromosome Location: 2p13.3
  •  Unigene: 170009
NBT00644