Flow Cytometric Analysis of PFA-fixed HeLa cells. PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A7) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A7) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
SDS-PAGE Analysis. Purified PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A7). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A7).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Arginine methylation is an irreversible protein modification catalyzed by Arginine methyltransferases, such as PRMT7, which uses S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport and RNA splicing. PRMT7 has two methyltransferase domains, each containing a putative AdoMet-binding motif. The N-terminal methyltransferase domain closely resembles the catalytic core of PRMT5, and the C-terminal domain is most similar to that of PRMT1. Three PRMT7 splice variants have been identified by database analysis. PRMT7 is localized to the nucleus and cytoplasm and moderate expression is observed in adult brain and lung tissues.