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Home >> Antibodies >> Lactotransferrin / Lactoferrin / LTF

Lactotransferrin / Lactoferrin / LTF

Mouse Monoclonal Antibody [Clone LTF/4073]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human breaststained with Lactotransferrin Mouse Monoclonal Antibody (LTF/4073). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

Immunofluorescence Analysis of PFA-fixed MCF-7 cells stained using Lactotransferrin Mouse Monoclonal Antibody (LTF/4073) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).

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Flow cytometric analysis of PFA-fixed MCF-7 cells. Lactotransferrin Mouse Monoclonal Antibody (LTF/4073) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red)

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Lactotransferrin Mouse Monoclonal Antibody (LTF/4073).

Product Details

Synonyms

GIG12; Growth inhibiting protein 12; HLF2; Kaliocin 1; Lactoferrin; Lactoferroxin-C; Lactotransferrin; LF; LTF; Neutrophil lactoferrin; Talalactoferrin

Positive Control

MCF-7 cells. Human lactating breast or prostate tissue.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa614-645) of human Lactotransferrin protein (exact sequence is proprietary)

Cellular Localization

Cytoplasm. Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

78kDa

Specificity & Comments

Ferritin and transferrins manage necessary iron-binding functions for iron metabolism. Transferrins comprise a class of single-chain, two-sited, metal-binding proteins expressed throughout the fluid and cells of vertebrates. The three major types of transferrin include serotransferrin, lactotransferrin (lactoferrin) and ovotransferrin. Lactoferrin is found in milk, tears and leukocytes. It degrades an IgA1protease secreted by Haemophilus influenzae and, consequently, allows the human IgA1antibody to effectively abolish Haemophilus influenzae colonization. Lactoferrin also attenuates the pathogenic potential of Haemophilus influenzae by proteolytic degradation of the Hap adhesin. While lactoferrin may aid in the transmission of human T cell leukemiavirus type 1, it inhibits HIV-1 replication at the level of viral fusion and entry into cells. The inhibitory effects of lactoferrin on mixed lymphocyte reactions suggest that it may have the ability to sense the activation status of lymphocytes.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lemma, S.A., et al. Carcinogenesis. 2017 Aug 1;38(8):812-820.
  2. Cutone, A., et al. 2019. Cell. Signal. 65: 109461.

Bioinformatics

  •  Entrez Gene ID: 4057
  •  Gene Symbol: LTF
  •  SwissProt: IDP02788
  •  Chromosome Location: 3q21.31
  •  Unigene: 529517