Flow Cytometric Analysis of PFA-fixed HeLa cells. JUNB Mouse Monoclonal Antibody (PCRP-JUNB-3G2) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Immunofluorescence Analysis of PFA-HeLa cells. JUNB Mouse Monoclonal Antibody (PCRP-JUNB-3G2) followed by goat anti-mouse IgG-CF488 (green). Phalloidin counterstain (red).
SDS-PAGE Analysis Purified JUNB Mouse Monoclonal Antibody (PCRP-JUNB-3G2). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using JUNB Mouse Monoclonal Antibody (PCRP-JUNB-3G2).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.