2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> DMRT2(Transcription Factor)

DMRT2(Transcription Factor)

MouseMonoclonal Antibody [Clone PCRP-DMRT2-1B11]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Flow Cytometric Analysis of PFA-fixed HeLacells. DMRT2Mouse Monoclonal Antibody (PCRP-DMRT2-1B11) followed bygoat anti-mouse IgG-CF488 (blue); isotypecontrol (red).

img

SDS-PAGE Analysis. Purified DMRT2 Mouse Monoclonal Antibody (PCRP-DMRT2-1B11). Confirmation of Integrity and Purity of Antibody.

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using DMRT2Mouse Monoclonal Antibody (PCRP-DMRT2-1D3).

Product Details

Synonyms

doublesex and mab-3 related transcription factor 2, doublesex-like 2 protein (DSXL-2), terra like protein antibody

Positive Control

HeLa or MCF-7 cells.

Known Applications & Suggested Dilutions

Flow Cyt, Western Blot         More Details

Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human DMRT2 protein

Cellular Localization

Nucleus

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b

Mol. Weight of Antigen

62kDa

Specificity & Comments

The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. Raymond CS et al. Hum Mol Genet 1999 Jun;8(6)989-996.

Bioinformatics

  •  Entrez Gene ID: 10655
  •  Gene Symbol: DMRT2
  •  SwissProt: Q9Y5R5
  •  Chromosome Location: 9p24.3
  •  Unigene: 59506