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Home >> Antibodies >> CD7 (T-Cell Leukemia Marker)

CD7 (T-Cell Leukemia Marker)

Mouse Monoclonal Antibody [Clone HuLy-m2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

GP40; Leu9; p41; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41

Positive Control

Jurkat, HUT-78, Molt-4, CEM cells or human peripheral blood lymphocytes. Lymph node and tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human thymocytes

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

40kDa

Specificity & Comments

Recognizes a protein of 40kDa, identified as CD7 (Workshop IV; Code T165). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sandrin et al. In Leukocyte Typing III, McMichael AJ (ed), Oxford University Press, Oxford, 216219 (1987).
  2. Saxena A, et al. Biologic and clinical significance of CD7 expression in acute myeloid leukemia. Am J Hematol. 1998;58(4):278-84.
  3. Rabinowich H, et al. J. Immunol. 1994 153(8):3504-3513.
  4. Knapp W et al. eds. Leukocyte typing IV, p341, Oxford University Press, Oxford, 1989.
  5. Miwa H, et al biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996;21:239-44.
  6. Emara M, et al. A human suppressor T-cell factor that inhibits T-cell replication by interaction with the IgM-Fc receptor (CD7). Hum Immunol. 1989;25(2):87-102.
  7. Thurlow PJ, A monoclonal antibody detecting a new human T cell antigen, HuLy-m2. Transplantation 1984, 38(2):143-147.

Bioinformatics

  •  Entrez Gene ID: 924
  •  Gene Symbol: CD7
  •  SwissProt: P09564
  •  Chromosome Location: 17q25.3
  •  Unigene: 186820
NBT01252