Formalin-fixed, paraffin-embedded human tonsil stained with CD6 Mouse Monoclonal Antibody (C6/372).
SDS-PAGE Analysis Purified CD6 Mouse Monoclonal Antibody (C6/372). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence analysis of PFA-fixed MOLT-4 cells. CD6 Mouse Monoclonal Antibody (C6/372) followed by goat anti-mouse IgG-CF488 (green). Nuclei stained with RedDot.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.