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Home >> Antibodies >> CD1b (T-Cell Surface Glycoprotein)

CD1b (T-Cell Surface Glycoprotein)

Mouse Monoclonal Antibody [Clone RIV12]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Flow Cytometric staining of human PBMCs using CD1b Mouse Monoclonal Antibody (RIV12).

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SDS-PAGE Analysis Purified CD1b Mouse Monoclonal Antibody (RIV12). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

A1 domain; CD1B; Cortical thymocyte antigen CD1B; hTa1 thymocyte antigen; Ly38; T cell surface glycoprotein CD1b; T6/Leu6

Positive Control

MOLT4 cells. Human thymus.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF         More Details

ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human peripheral lymphocytes

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

49kDa

Specificity & Comments

The Mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Maher JK and Kronenberg M. The role of CD1 molecules in immune responses to infection. Curr Opin Immunol 1997, 9(4):456-461Blumberg RS et al. Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol Rev 1995, 147:5-29.
  2. Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989
  3. Salamone MC et al. Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. II. Intracellular detection of CD1 antigens. Dis Markers 1990, 8(5):275-281.

Bioinformatics

  •  Entrez Gene ID: 910
  •  Gene Symbol: CD1B
  •  SwissProt: P29016
  •  Chromosome Location: 1q23.1
  •  Unigene: 1310
NBT00317