Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/2781).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Cathepsin D Mouse Monoclonal Antibody (CTSD/2781)
SDS-PAGE AnalysisPurified Cathepsin D Mouse Monoclonal Antibody (CTSD/2781).Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human liver tissue and MCF-7 cell lysates usingCathepsin D Mouse Monoclonal Antibody (CTSD/2781).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.