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PIP Antibodies

Gross cystic disease fluid protein 15 (GCDFP-15), also known as prolactin-inducible protein (PIP), is encoded by the gene PIP. It is located on chromosome 17q21.32. GCDFP-15 consists of 163 amino acids and has a molecular weight of approximately 15 kDa. This protein undergoes post-translational modifications, including phosphorylation and glycosylation, which can impact its stability, localization, and function. GCDFP-15 is primarily a secreted protein found in various bodily fluids, such as breast milk, sweat, and saliva. The exact function of GCDFP-15 is not fully understood, but it is believed to play a role in mammary gland development and lactation.

GCDFP-15 is predominantly expressed in the mammary glands, where it is regulated by prolactin, a hormone involved in milk production. Additionally, GCDFP-15 expression has been detected in certain other tissues, including salivary glands, sweat glands, and some types of cancer cells, where it serves as a marker in various cancers, particularly breast and salivary gland cancer. 

In breast cancer, GCDFP-15 expression is often associated with certain subtypes of the disease, such as estrogen receptor (ER)-positive and/or progesterone receptor (PR)-positive tumors. It has also been observed that GCDFP-15 is expressed in a subset of breast cancer cases, particularly those of ductal origin. Its expression may be used alongside other markers to aid in the diagnosis and classification of breast cancer subtypes. Additionally, GCDFP-15 expression has been suggested to have prognostic value, with some studies indicating that its presence may be associated with better outcomes in breast cancer patients.

In salivary gland cancer, GCDFP-15 expression is commonly observed in certain types of tumors, such as mammary analogue secretory carcinoma (MASC). Its detection can aid in the diagnosis and differentiation of MASC from other salivary gland neoplasms.

NeoBiotechnologies offers a variety of antibodies against GCDFP-15 that have been validated for flow cytometry, immunofluorescence, immunohistochemistry, and Western blotting, as well as a HuProt validated option. Additionally, we hold exclusive rights to GCDFP-15 antibodies available for licensing or collaboration [https://www.neobiotechnologies.com/shop/?s=GCDFP-15].


Prolactin-inducible protein, Gross cystic disease fluid protein 15, Prolactin-induced protein, Secretory actin-binding protein, gp17, BRST-2; GCDFP-15; gp17; GPIP4; Gross cystic disease fluid protein 15; Prolactin-induced protein (PIP); Prolactin-inducible protein (PIP); Secretory actin-binding protein (SABP)

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