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Home >> Antibodies >> CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors)

CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors)

Mouse Monoclonal Antibody [Clone KIT/982]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Western Blot Analysis of recombinant fragment of CD117 with CD117 Mouse Monoclonal Antibody (KIT/982).

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SDS-PAGE Analysis Purified CD117 Mouse Monoclonal Antibody (KIT/982). Confirmation of Integrity and Purity of Antibody

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Analysis of Protein Array containing more than 19,000 full-length human proteins using CD117 Mouse Monoclonal Antibody (KIT/982).

Product Details

Synonyms

p145; Steel Factor Receptor; Stem Cell Factor Receptor (SCF-Receptor); Mast Cell Growth Factor Receptor

Positive Control

Esophagus, Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml for 2 hours at RT)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa100-300) of human CD117 protein (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~145kDa

Specificity & Comments

This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Zafrani B, et. al. Histopathology 2000; 37(6), 536-545.
  2. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474-1481.

Bioinformatics

  •  Entrez Gene ID: 3815
  •  Gene Symbol: KIT
  •  SwissProt: P10721
  •  Chromosome Location: 4q12
  •  Unigene: 479754
NBT00982