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SSTR2 Antibody [SSTR2/7532]

In Stock
Catalog Number Formulation Size Price
6752-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6752-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6752-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

SSTRs (for somatostatin receptors) represent a family of G protein-coupled receptors which mediate the diverse biological actions of somatostatin (SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1,2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Lambda
Cellular Localization
Cell surface.
Gene Name
Positive Control
colon and liver.|Human Cerebrum and kidney. In lesser amounts in jejunum
Immunogen
Recombinant fragment (around aa300-500) of human SSTR2 (exact sequence is proprietary)
Alternate Names
Somatostatin receptor type 2, SRIF-1, Somatostatin receptor type 2; SRIF-1; SRIF1; SS-2-R; SS2-R; SS2R; SST2; SSTR2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
SSTR2/7532
Chromosome Location
17q25.1
Mol. Weight of Antigen
87/148 kDa

Functions

  • Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Key References

  • Mimori, T., et al. 1981. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest. 68: 611-620.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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