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P-Cadherin (CDH3) Antibody [12H6]

In Stock
Catalog Number Formulation Size Price
1001-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
1001-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
1001-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
P-Cadherin (CDH3) Antibody

SDS-PAGE Analysis of Purified P-Cadherin Mouse Monoclonal Antibody (12H6). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Recognizes a protein of 116kDa, identified as P-Cadherin-1 (CDH3). Itis a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Human
Research Areas
Basal Cell Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
CDH3
Positive Control
A431 or PC-3 cells. Pancreas, Placenta or Prostate.
Immunogen
Recombinant human P-cadherin fusion protein
Alternate Names
Cadherin-3, Placental cadherin, Cadherin 3 type 1; Cadherin-3; Cadp; Calcium dependent adhesion protein placental; CDH3; CDHP; HJMD; P-cadherin (Placental); PCAD; Placental cadherin

Database Links

Entrez Gene ID
1001
SwissProt
P22223

Additional Information

Clone
12H6
Chromosome Location
16q22.1
Mol. Weight of Antigen
116kDa

Related Antibodies

View All CDH3 Antibodies

Functions

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Key References

  • Sanders DS, Perry I, Hardy R, Jankowski J. Aberrant P-cadherin expression is a feature of clonal expansion in the gastrointestinal tract associated with repair and neoplasia. J Pathol. 2000 Apr;190(5):526-30.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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