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TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein) Antibody [TOM1L1/4690]

Additional information

Catalog Number: 10040-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
10040-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
10040-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
10040-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein) Antibody

IHC analysis of formalin-fixed, paraffin-embedded human kidney. TOM1L1/4690 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

TOM1L1 (Target of Myb1 Like 1 Membrane Trafficking Protein) Antibody - Image 2

IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using TOM1L1/4690 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
TOM1L1/4690
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Endosome membrane, Golgi apparatus, Golgi stack, Membrane
Gene Name
TOM1L1
Positive Control
Human kidney.
Immunogen
Recombinant full-length human TOM1L1 protein
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
10040
SwissProt
O75674
Chromosome Location
17q22
Mol. Weight of Antigen
53kDa.
Alternate Names
TOM1-like protein 1, Src-activating and signaling molecule protein, Target of Myb-like protein 1, 2310045L10Rik; C80573; OK/KNS CL.3; Src activating and signaling molecule; SRCASM; Target of Myb like protein 1; Target of myb1 (chicken) homolog like 1; Target of myb1 (chicken) like 1; TOM1 like protein 1; TOM1L1 protein

Summary

Tom1 (target of Myb 1) is a 492 amino acid cytoplasmic protein that belongs to the Tom1 family. Widely expressed with highest expression in heart, liver, placenta and skeletal muscle, Tom1 is thought to be involved in intracellular trafficking and may be associated with the translocation of ubiquitinated proteins to early endosomes for degradation. Tom1 contains one GAT domain and one VHS domain through which it interacts and complexes with proteins such as Tollip and endofin (also known as SARA). These interactions recruit Tom1 to the endosome, allowing it to participate in the endosomal trafficking of ubiquitin-tagged proteins.

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