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Recombinant Granzyme B (NK/T-Cell Lymphoma Marker) Antibody [GZMB/6530R]

Additional information

Catalog Number: 3002-RBM10
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3002-RBM10-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3002-RBM10-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3002-RBM10-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Granzyme B (NK/T-Cell Lymphoma Marker) Antibody

Formalin-fixed, paraffin-embedded human spleen stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).

Recombinant Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human tonsil stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).

Recombinant Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified GZMB Recombinant Rabbit Monoclonal Antibody (GZMB/6530R). Confirmation of Integrity and Purity of Antibody.

Granzyme B Antibody in Western Blot (WB)

Granzyme B Antibody in Western Blot (WB)

Western Blot Analysis of Human Kidney, Human Lung and Human Spleen tissue lysates using Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).

Granzyme B Antibody in Western Blot (WB)

Granzyme B Antibody in Western Blot (WB)

Western Blot Analysis of Spleen and Lung tissue lysates of different species using Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
GZMB/6530R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytolytic granule, Secreted
Gene Name
GZMB
Positive Control
A431 cells. Human tonsil, spleen or Hodgkin s Lymphoma tissue (IHC). Human Kidney, Human Lung
Immunogen
Recombinant fragment (around aa73-187) of the human Granzyme B protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:1985927, PubMed:3262682, PubMed:3263427). It cleaves after Asp (PubMed:1985927, PubMed:8258716). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:31953257, PubMed:32188940). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3002
SwissProt
P10144
Chromosome Location
14q12
Mol. Weight of Antigen
27.72kDa
Alternate Names
Granzyme B, C11|CCPI|CGL-1|CGL1|CSP-B|CSPB|CTLA1|CTSGL1|HLP|SECT

Summary

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface ‘nonself’ antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

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