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MUC13 / Mucin 13 Antibody [MUC13/13112]

Additional information

Catalog Number: 56667-MSM2
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
56667-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
56667-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
56667-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
MUC13 Antibody in SDS-PAGE

MUC13 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified MUC13 Mouse Monoclonal Antibody (MUC13/13112). Confirmation of Purity and Integrity of Antibody.

Mucin 13 Antibody in Immunohistochemistry (IHC (P))

Mucin 13 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human small intestine stained with Mucin 13 (MUC13) Mouse Monoclonal Antibody (MUC13/13112). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
MUC13/13112
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
MUC13
Positive Control
Human colon or small intestine.
Immunogen
Recombinant fragment (around aa100-300) of human MUC13 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
Key References
  • Doxtater, K., Tripathi, M. K., er al. (2023). MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Life science alliance, 6(12), e202301975. https://doi.org/10.26508/lsa.202301975
  • Pang, Y., Zhang, Y., et al. (2022). MUC13 promotes lung cancer development and progression by activating ERK signaling. Oncology letters, 23(1), 37. https://doi.org/10.3892/ol.2021.13155
  • Han, Y., Chen, G., et al. (2023). MUC13 promotes the development of esophageal cancer by upregulating the expression of O-glycan process-related molecules. Discover oncology, 14(1), 123. https://doi.org/10.1007/s12672-023-00713-3
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
56667
SwissProt
Q9H3R2
Chromosome Location
3q21.2
Mol. Weight of Antigen
58kDa
Alternate Names
Mucin-13, Mucin-13; MUC-13; Down-regulated in colon cancer 1; UNQ6194/PRO20221; MUC13; RECC; DRCC1, DRCC1; MUC-13

Summary

Mucins are epithelial glycoproteins with a high content of clustered oligosaccharides that are O-glycoside linked to tandem repeat peptides rich in threonine, serine and proline. Mucin 13 (MUC13), also designated downregulated in colon cancer 1 (DRCC1), is an epithelial and hemopoietic type I membrane protein that undergoes secretion and influences gastrointestinal mucosa levels. It is most abundant in epithelial tissues of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach. Mucin 13 is a good differentiation marker for gastrointestinal mucosa and may also indicate certain gastric tumors. It localizes to the apical membrane of both columnar and goblet cells in the gastrointestinal tract, and within goblet cell thecae. Mucin 13 is a cleaved protein, and the b subunit, containing the cytoplasmic tail, can homodimerize.

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