Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Lewis Y Monoclonal Antibody (LWY/1463).

Lewis Y (Tumor Marker) [LWY/1463]

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Summary

This antibody recognizes a carbohydrate epitope present on tumor-associated Lewis Y antigen (Fucalpha1-2Galbeta1-4/3[Fucalpha1-3/4]GlcNAcbeta-). Lewis Y is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis Y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.

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Product Properties & Targets

Host
Mouse
Species Reactivity
Human
Isotype
IgG1
Cellular Localization
N/A
Gene Name
N/A
Mol. Weight of Antigen
Multiple
Immunogen
Human colon carcinoma cells

Database Links

Entrez Gene ID
Not Applicable
Unigene
Not Applicable
SwissProt
N/A

Additional Information

Clone
LWY/1463
Human Gene Symbol
Not Applicable
Chromosome Location
Not Applicable

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
  • Optimal dilution for a specific application should be determined.

Key References

  • Christensen PA, Danielczyk A, Ravn P, Stahn R, Karsten U, Goletz S. A monoclonal antibody to Lewis Y/Lewis b revealing mimicry of the histone H1 to carbohydrate structures. Scand J Immunol. 2007 Apr;65(4):362-7.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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