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Interferon alpha-1 (IFNA1) Antibody [2-48]

Additional information

Catalog Number: 3439-MSM1
Reactivity:

Gene:

,

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3439-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3439-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3439-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Interferon alpha-1 (IFNA1) Antibody

SDS-PAGE Analysis of Purified Interferon alpha-1 Mouse Monoclonal Antibody (2-48). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
2-48
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
IFNA1, IFNA13
Positive Control
Stimulated human peripheral blood mononuclear cells.
Immunogen
Purified recombinant human IFN-alpha1
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Key References
  • Sen GC et al. J Biol Chem 1992, 267(8):5017-5020
  • Pestka S et al. Annu Rev Biochem 1987, 56:727-777
  • Capon DJ et al. Mol Cell Biol 1985, 5(4):768-779
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3439
SwissProt
P01562
Chromosome Location
9q22
Mol. Weight of Antigen
16-27kDa
Alternate Names
Interferon alpha-1/13, Interferon alpha-D, IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D

Summary

This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

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