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HEG1 (Marker of Malignant Mesothelioma) Antibody [HEG1/9445]

In Stock
Catalog Number Formulation Size Price
57493-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
57493-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
57493-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Predicted to enable calcium ion binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Located in cell-cell junction. [provided by Alliance of Genome Resources, Apr 2022]

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Cell junction, Cell membrane, Cytoplasm, Secreted
Gene Name
Positive Control
Malignant mesothelioma or thyroid.
Immunogen
Recombinant fragment (around aa1-400) of human HEG1 protein (exact sequence is proprietary)
Alternate Names
protein HEG homolog 1, HEG antibody; HEG1 antibody; HEG1_HUMAN antibody; KIAA1237 antibody; MST112 antibody; MSTP112 antibody; Protein HEG homolog 1 antibody, HEG; MST112; MSTP112

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
HEG1/9445
Chromosome Location
3q21.2
Mol. Weight of Antigen
147kDa

Key References

  • Zou X, Zhang Y, Wang N, et al. HEG1 as a novel potential biomarker for the prognosis of lung adenocarcinoma. Cancer Med. 2023;12(3):3288-3298. doi:10.1002/cam4.5081
  • Churg A, Naso JR. Hypothesis: HEG1 and claudin-4 staining will allow a diagnosis of epithelioid and biphasic mesothelioma versus non-small-cell lung carcinoma with only two stains in most cases. Histopathology. 2023;82(3):385-392. doi:10.1111/his.14783
  • Naso JR, Tsuji S, Churg A. HEG1 Is a Highly Specific and Sensitive Marker of Epithelioid Malignant Mesothelioma. Am J Surg Pathol. 2020;44(8):1143-1148. doi:10.1097/PAS.0000000000001469

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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