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HIC2 (Hypermethylated in cancer 2) (Transcriptional Repressor) Antibody [PCRP-HIC2-2F8]

In Stock
Catalog Number Formulation Size Price
23119-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
23119-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
23119-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

HIC2 (HIC ZBTB Transcriptional Repressor 2) is a Protein Coding gene. Diseases associated with HIC2 include Orofaciodigital Syndrome X and Simpson-Golabi-Behmel Syndrome, Type 1. HIC2 contains 5 C2H2-type zinc fingers and 1 BTB (POZ) domain. It belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily and is a transcriptional repressor. It is a transcription activator of SIRT1.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa cells.
Immunogen
Recombinant full-length human HIC2protein
Alternate Names
Hypermethylated in cancer 2 protein, HIC1-related gene on chromosome 22 protein, Hic-3, Zinc finger and BTB domain-containing protein 30, HRG22, KIAA1020, ZBTB30, ZNF907

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-HIC2-2F8
Chromosome Location
22q11.21
Mol. Weight of Antigen
66.1kDa

Functions

  • Transcriptional repressor.

Key References

  • Blackshaw S., et al. Nature methods 15.5 (2018 May): 330-338.
  • Song JY, et al. FEBS Lett, 2019 Jul. PMID 31127867

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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