Cystatin B (Marker of Epithelial Ovarian Cancer Progression) [CPTC-CSTB-3]



Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with papain and the cathepsins B, H, and L. cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.

Product Properties & Targets

Species Reactivity
Cellular Localization
Cytoplasm, Nucleus
Light Chain
Gene Name
Positive Control
HEK293T or U-87 MG cells. Human tonsil.
Recombinant full-length human Cystatin B protein
Alternate Names
Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CHROW21; CPI-B; CST 6; CSTB; CYTB; Stefin B; EPM1; Liver thiol proteinase inhibitor; PME; STFB; ULD

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

Known Applications & Suggested Dilutions

  • Western Blot (1-2ug/ml)
  • ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Wang X, et al. Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF- signaling pathway. Int J Oncol. 2014 Apr;44(4):1099-106.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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