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Cystatin B (Marker of Epithelial Ovarian Cancer Progression) Antibody [CPTC-CSTB-3]

Additional information

Catalog Number: 1476-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
1476-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
1476-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
1476-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Cystatin B (Marker of Epithelial Ovarian Cancer Progression) Antibody

SDS-PAGE Analysis of Purified Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3). Confirmation of Purity and Integrity of Antibody.

Cystatin B (Marker of Epithelial Ovarian Cancer Progression) Antibody - Image 2

Formalin-fixed, paraffin-embedded human lung stained with Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
CPTC-CSTB-3
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
CSTB
Positive Control
HEK293T or U-87 MG cells. Human tonsil.
Immunogen
Recombinant full-length human Cystatin B protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Key References
  • Wang X, et al. Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF- signaling pathway. Int J Oncol. 2014 Apr;44(4):1099-106.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
1476
SwissProt
P04080
Chromosome Location
21q22.3
Mol. Weight of Antigen
12kDa
Alternate Names
Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CHROW21; CPI-B; CST 6; CSTB; CYTB; Stefin B; EPM1; Liver thiol proteinase inhibitor; PME; STFB; ULD

Summary

Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with papain and the cathepsins B, H, and L. cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.

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