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Carbonic Anhydrase VIII Antibody [CA8/6572]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
767-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
767-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
767-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Gene Name
CA8
Positive Control
Human cerebellum. Selective expression in Purkinje cells. HEK-293 or K-562 cell lines.
Immunogen
Recombinant full-length human CA8 protein
Alternate Names
Carbonic anhydrase-related protein, Carbonic anhydrase VIII, CA-VIII; CALS; CARP; MGC120502; MGC99509

Database Links

Entrez Gene ID
767
SwissProt

Additional Information

Clone
CA8/6572
Chromosome Location
8q12.1
Mol. Weight of Antigen
32.97kDa

Functions

  • Does not have a carbonic anhydrase catalytic activity.

Key References

  • Shimobayashi, E, et al. Molecular Neurobiology., U.S. National Library of Medicine, Oct. 2016.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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