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bFGF / FGF2 Antibody [FGF2/7364]

In Stock
Catalog Number Formulation Size Price
2247-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2247-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2247-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human placenta stained with FGF2 Mouse Monoclonal Antibody (FGF2/7364). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human placenta stained with FGF2 Mouse Monoclonal Antibody (FGF2/7364). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis of Purified FGF2 Mouse Monoclonal Antibody (FGF2/7364). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified FGF2 Mouse Monoclonal Antibody (FGF2/7364). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10-FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Breast Cancer, Cardiovascular, Developmental Biology, Immunology, AKT Signaling, Angiogenesis, Cytokine Signaling, Infectious Disease, MAPK Signaling, Mesenchymal Stem Cell Differentiation, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Signal Transduction, Stem Cell Differentiation
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Nucleus, Secreted
Gene Name
FGF2
Positive Control
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Immunogen
Recombinant fragment (around aa 7-96) of human FGF2 protein (exact sequence is proprietary)
Alternate Names
Fibroblast growth factor 2, Basic fibroblast growth factor (bFGF), Heparin-binding growth factor 2 (HBGF-2), Basic fibroblast growth factor bFGF; BFGF; Fgf2; FGF2 basic; FGFB; Fibroblast growth factor, basic; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Prostatropin

Database Links

Entrez Gene ID
2247
SwissProt
P09038

Additional Information

Clone
FGF2/7364
Chromosome Location
4q28.1
Mol. Weight of Antigen
18/21/24kDa

Related Antibodies

View All FGF2 Antibodies

Functions

  • Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.

Key References

  • Litwin, M., et al. 2015. The role of FGF-2 in migration and tubulogenesis of endothelial progenitor cells in relation to pro-angiogenic growth factor production. Mol. Cell. Biochem. 410: 131-142.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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